Physiology and Biophysics Discipline

Center for Neurobiology of Stress Resilience and Psychiatric Disorders

Dr. Eugene Dimitrov earned his medical degree in 1992, and he earned a PhD in neuroscience in 2007.

Research Projects

My research interests are focused on the interdigitation of stress and pain pathways. I use a systemic approach to examine the contribution of subsets of GABAergic neurons in amygdala to the generation of affective disorders. I use transgenic mice lines and apply technologies such as viral vectors and pharmacogenetics to discover and describe the function of various neurotransmitter systems on pain associated mood disorders.

Publications

• Cardenas A, Caniglia J, Keljalic D, Dimitrov E. Sex Differences in the Development of Anxiodepressive-Like Behavior of Mice Subjected to Sciatic Nerve Cuffing. (March 2020) Pain, PMID: 32205527.
• Andreoli, M., Marketkar, T., and Dimitrov E. Contribution of amygdala CRF neurons to chronic pain. (2017) Exp Neurol, 298(Pt A):1-12
• Usdin T.B. and Dimitrov E. L.  The Effects of Extended Pain on Behavior: Recent Progress, (2016) Neuroscientist, 22(5):521-33
• Dimitrov E., Tsuda, M. and Usdin T. B. Anxiety- And Depression-Like Behavior and Impaired Neurogenesis Evoked by Peripheral Neuropathy Persist Following Resolution of Prolonged Tactile Hypersensitivity, (2014) J Neuroscience, 34(37):12304-12
• Dimitrov E. L., Kuo J., Kohno K. and Usdin T. B. Tuberoinfundibular Peptide of 39 Residues Control of Norepinephrine Release in Chronic and Inflammatory Pain, (2013) PNAS, 110(32):13156-61
• Dimitrov E. L., Yanagawa, Y. and Usdin T. B. Forebrain GABAergic Projections to Locus Ceruleus in Mouse, (2013) J Comp Neurology, 521 (10):2373
• Dobolyi A., Dimitrov E., Palkovits M. and Usdin T.B. The Neuroendocrine Functions of the Parathyroid Hormone 2 Receptor, (2012) Front Endocrinol (Lausanne), 3(121):1-10
• Gao J. L., Schneider E. H., Dimitrov E. L., Haun F., Pham T. M., Mohammed A. H., Usdin T. B. and Murphy P.M. Reduced Fear Memory and Anxiety-like Behavior in Mice Lacking Formylpeptide Receptor 1, (2011) Behav Genetics, 41(5):724-733
• Dimitrov E., Kim Y. and Usdin T. Regulation of Hypothalamic Signaling by Tuberoinfundibular Peptide of 39 Residues Is Critical for the Response to Cold: A Novel Peptidergic Mechanism of Thermoregulation, (2011) J Neuroscience, 31(49):18166-11179
• Dimitrov E., Petrus E. and Usdin T. B. Tuberoinfundibular Peptide of 39 residues (TIP39) Signaling Modulates Acute and Tonic Nociception, (2010) Exp Neurology, 226: 68-83
• Dimitrov E. and Usdin T. B. Tuberoinjundibular Peptide of 39 Residues Modulates the Mouse Hypothalamic-Pituitary-Adrenal Axis Via Paraventricular Glutamatergic Neurons, (2010) J Comp Neurology, 518(21): 4375-4395
• Dimitrov E., Bago A. G., Saunders R., Seress L., Palkovits M., Usdin T. B. and Dobolyi A. Parathyroid Hormone 2 Receptor and Its Endogenous Ligand Tuberoinfundibular Peptide of 39 Residues are Concentrated in Endocrine, Viscerosecretory and Auditory Brain Regions in Macaque and Human, (2009) Neuroscience, 162:128-147
• Dimitrov E. L., DeJoseph M. R., Brownfield M. S. and Urban J. H. Involvement of Neuropeptide Y Y1 Receptors in the Regulation of Neuroendocrine Corticotropin­ Releasing Hormone Neuronal Activity, (2007) Endocrinology, 148(8): 3666 -3673