Dr. Pengli Bu, Assistant Professor of Pharmaceutical Sciences, joined the College of Pharmacy in October of 2019. Dr. Bu received her BS in Biology from Shan Dong University, Shan Dong province, P.R. China and her MS in Biochemistry & Molecular Biology from Peking Union Medical College (now Tsinghua University Medical School), Beijing, P.R. China. She obtained her PhD in Toxicology from the department of Pharmacology, Toxicology, and Therapeutics at the University of Kansas Medical Center, where she then continued her postdoctoral training in the department of Pathology & Laboratory Medicine. Dr. Bu then moved to St. John's University in New York, where she continued her research as a postdoctoral researcher and taught core-curriculum courses in the departments of Biological Sciences and Pharmaceutical Sciences as an Adjunct Assistant Professor.

Throughout her training and research experience, Dr. Bu has employed cell lines, stem cells, and genetically engineered mouse models as research tools to investigate mechanisms underlying normal and disease conditions. By combining her toxicologist background and her expertise in endocrinology and reproductive biology, Dr. Bu’s research focuses on how environmental contaminants adversely impact male reproductive functions. Dr. Bu’s investigation focuses on the molecular mechanisms linking chemical stimulus to pathological outcome at both cellular and organismal levels.

CURRICULUM VITAE

Courses

• Fundamentals of Pharmacology
• Pharmacology I
• Pharmacology II
• Pharmacology IIII

Recent Peer-Reviewed Publications

1. Bu P, Nagar S, Bhagwat MS, Shah A, Zeng J, and Vancura A. DNA damage response activates respiration and thereby enlarges dNTP pools to promote cell survival in budding yeast. Journal of Biological Chemistry (2019) PMID: 31073026.
2. Vancura A, Bu P, Bhagwat M, Zeng J, and Vancurova I. Metformin as an anticancer agent. Trends in Pharmacological Sciences (2018) PMID: 30150001.
3. Vancura A, Nagar S, Kaur P, Bu P, Bhagwat M, Vancurova I. Reciprocal Regulation of AMPK/SNF1 and Protein Acetylation. International Journal of Molecular Sciences (2018) PMID:30366365.
4. Zou Y, Uddin MM, Padmanabhan S, Zhu Y, Bu P, Vancura A, and Vancurova I. The proto-oncogene Bcl3 induces immune checkpoint PD-L1 expression, mediating proliferation of ovarian cancer cells. Journal of Biological Chemistry (2017) PMID: 28167529.
5. Zhang T, Bu P, Zeng J and Vancura A. Heme induces metabolic switch from fermentation to respiration through activation of Hap1p and the HAP complex. Journal of Biological Chemistry (2017) PMID: 28830930.
6. Bu P, Le Y, Zhang Y, Zhang Y, and Cheng X. Inactivation of Stat5 signaling by Berberine induced mouse and human sodium-taurocholate cotransporting polypeptide (Ntcp/NTCP) expression. Journal of Biological Chemistry (2017) PMID: 28154180.
7. Bu P, Le Y, Zhang Y, and Cheng X. Hormonal and chemical regulation of Glut9 transporter in mice. Journal of Pharmacology and Experimental Therapeutics (JPET) (2016) PMID: 27807007.
8. Le Y, Chen L, Zhang Y, Bu P, Dai G, and Cheng X. Epalrestat induced hepatic oxidative stress and liver fibrosis. Toxicological Sciences (2017) PMID: 28204799.
9. Gatla HR, Zou Y, Uddin MM, Singha B, Bu P, Vancura A, and Vancurova I. Histone deacetylase (HDAC) inhibition induces IκB Kinase (IKK)-dependent interleukin-8/CXCL8 expression in ovarian cancer cells. Journal of Biological Chemistry (2017) PMID: 28167529.
10. Vispute SG, Bu P, Le Y, Chen L, and Cheng X. Fibroblast growth factor (Fgf) 21 is a target gene of Glucocorticoid Receptor. Toxicology (2017) PMID: 28088388.
11. Bu P, Ji Y, Narayanan S, Dalrymple D, Cheng X, and Serajuddin ATM. Assessment of cell viability and permeation enhancement in presence of lipid-based self-emulsifying drug delivery systems using Caco-2 cell model: Polysorbate 80 as the surfactant. European Journal of Pharmaceutical Sciences (2016) PMID: 28024890.
12. Bu P, Narayanan S, Dalrymple D, Cheng X, and Serajuddin ATM. Cytotoxicity assessment of lipid-based self-emulsifying drug delivery system in Caco-2 cell model: Cremophor EL as the surfactant. European Journal of Pharmaceutical Sciences (2016) PMID:27328127.
13. Bu P, Yagi S, Shiota K, Alam S, Vivian J, Wolfe MW, Rumi M, Chakraborty D, Kubota K, Dhakal P and Soares M. Origin of a rapidly evolving homeostatic control system programming testis function. Journal of Endocrinology (2017) PMID: 28576872.
14. Xie M, Bu P, Li F, Lan S, Wu H, Yuan L, and Wang Y. Neonatal Bisphenol A exposure induces meiotic arrest and apoptosis of spermatogenic cells. Oncotarget (2016) PMID: 26863571.
15. Bu P, Alam SMK, Dhakal P, Vivian JL and Soares MJ. A prolactin family paralog regulates placental adaptations to a physiological stressor. Biology of Reproduction (2016) PMID: 26985002.
16. Soares MJ, Chakraborty D, Renaud SJ, Kubota K, Bu P, and Rumi MAK. Regulatory pathways controlling the endovascular invasive trophoblast cell lineage. Journal of Reproduction and Development (2012) PMID: 22790871.
17. Konno T, Graham AR, Rempel LA, Ho-Chen JK, Alam SMK, Bu P, Rumi MAK, and Soares MJ. Subfertility linked to combined luteal insufficiency and uterine progesterone resistance. Endocrinology (2010) PMID: 20660062.
18. Yang H, Bushue N, Bu P, and Wan YJ. Induction and intracellular localization of Nur77 dictate fenretinide-induced apoptosis of human liver cancer cells. Biochem. Pharmacol. (2010) PMID:19912993.
19. Dai G, He L, Bu P, and Wan YJ. Pregnane X receptor is essential for normal progression of liver regeneration. Hepatology (2008) PMID: 18167061.
20. Bu P and Wan YJ. Fenretinide-induced apoptosis of Huh-7 hepatocellular carcinoma is retinoic acid receptor beta dependent. BMC Cancer (2007) PMID: 18166136.