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Cancer Cell Biology, Immunology, and Infection

We study the molecular basis of virus-induced cancers, the role of inflammation in cancer and autoimmune diseases (IBD, IBS, and others), the etiological agents of infectious diseases, and host defense mechanisms.
Team Diseases

In this section

In this section

Johnny He

Johnny He, PhD

Director, Center for Cancer Cell Biology, Immunology, and Infection

johnny​.he​@rosalindfranklin​.edu
Biography

 

  • Johnny J. He - Center Director
    • HIV infection and pathogenesis in astrocytes
    • Molecular mechanisms of HIV Tat protein neurotoxicity
    • Tip110 and tumorigenesis
  • Kenneth D. Beaman
    • The role of vacuolar ATP-ase that is involved in ovarian cancer-related inflammation and pregnancy.
  • Kwang Poo Chang
    • The Leishmania based photo-vaccines against infectious and malignant diseases.
  • Svetlana Dambaeva
    • Immune response at the maternal-fetal interface and analysis of immune mechanisms of infertility and recurrent pregnancy loss
  • Joseph X. DiMario
    • The cellular and molecular mechanisms that regulate the development and differentiation of skeletal muscle fibers and their respective phenotypes.
  • Mirek Dundr
    • Compartmentalization of the nucleus as it contributes to genome function and regulates genome organization in cancer.
  • David N. Everly
    • Epstein-Barr virus (EBV) transforming protein and its role in manipulating cellular signaling pathways involved in tumor formation (Note: EBV is associated with Burkitt’s lymphoma, nasopharyngeal carcinoma, as well as certain types of Hodgkin disease and gastric cancers).
    • Constitutive inflammatory signaling in virally induced cancer and the role of viruses in multiple sclerosis.
  • Hongkyun Kim
    • Identification and characterization of genes responsible for neuromuscular diseases, including muscular dystrophies.
  • Ying Liu
    • HIV latency in astrocytes.
    • Tip110 and HIV gene transcription control.
  • Gustavo J. Martinez
    • The transcriptional regulation of CD8+ and follicular helper T cell responses against acute and chronic viral infections.
  • Fabio Re
    • The role of toll-like receptors and inflammasomes during bacterial infections and vaccination.
  • Joseph Reynolds
    • The role of the IL-17 family of cytokines in autoimmune inflammation and mucosal immunity.
  • Neelam Sharma-Walia
    • Arachidonic acid pathway in KSHV pathogenesis.
    • The role of inflammatory COX-2 and lipoxins and anti-inflammatory leukotrienes role in inflammatory breast cancer and virus associated cancers.
  • Rahul Vijay
    • The precise role played by the early short-lived plasmablasts in various infections.
    • Identification of immunotherapeutic approaches to restrain infection-induced plasmablasts.
  • Carl White
    • Modulation of reactive oxygen species and calcium signaling pathways in the smooth muscle cells of resistance arterioles in mouse models of diabetes.